A Global Genetic Model of DYT1 Dystonia

TECHNOLOGY NUMBER: 6220
Technology No. 6220

INNOVATION

Using a unique genetic strategy, we developed the first mouse model of primary dystonia to exhibit overt abnormal dystonic-like twisting movements. We combined the DYT1 knock-in allele, a floxed Tor1a allele, and Nestin Cre in order to mimic the dominant negative disease mechanism.  

  • swap_vertical_circlemode_editInventor (2)
    William Dauer
    Richard Liang
  • swap_vertical_circlecloud_downloadSupporting documents (1)
    Product brochure
    A Global Genetic Model of DYT1 Dystonia.pdf
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