Col2a1-tTA Transgenic Mice

TECHNOLOGY NUMBER: 2022-034
Technology No. 2022-034
MOUSE
1

INNOVATION

Col2a1-tTA transgenic mice express tTA (tetracycline-controlled transactivator) from the chondrocyte-specific mouse Col2a1 (collagen, type II, alpha 1) promoter/enhancer. When combined with a tetO/TRE transgene, expression of the target gene of interest can be blocked in chondrocytes by administration of doxycycline in a "Tet-Off" system. This mouse enables functional manipulation of chondrocytes.


ADDITIONAL DETAILS

Jackson https://www.jax.org/strain/035969
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    Product brochure
    Col2a1-tTA Transgenic Mice.pdf
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