Fabrication of Bile Salt and Corticosteroid Microparticles for Controlled Release Drug Delivery Applications

OVERVIEW

• Uses gold ions at the interface to construct solid bile salt carriers with precise particle size and shape.
• Controlled-release drug delivery for liver, metabolic, dermatological, and inflammatory conditions.

MODALITY

Gold-cholate composite microparticles engineered via a novel oil-water interface chemical process for solid bile salt drug delivery.

INDICATION

Chronic or targeted therapies across liver disorders, metabolic conditions, dermatological treatments, and inflammatory disorders.

INTELLECTUAL PROPERTY

BACKGROUND

In pharmaceuticals for liver disease, dermatologic applications, and metabolic or inflammatory disorders, consistent and tightly regulated dosing is vital. Historically, developers have relied on standard drug particle fabrication methods, including prior approaches that incorporated gold nanoparticles within a particle matrix to assist carrier formulation. However, conventional controlled-release systems face notable shortcomings: traditional approaches lack fine control over particle geometry, fail to utilize solid bile salts as drug carriers, and struggle to deliver consistently uniform structures essential for precise pharmacokinetics and targeted tissue delivery. Consequently, there is a strong and unmet need for advanced controlled-release drug delivery platforms. Achieving optimal efficacy and safety in next-generation injectables and topical formulations requires an improved chemical process that can reliably customize particle size and shape, ensuring predictable degradation and slow, tailored therapeutic release without sacrificing structural uniformity.

INNOVATION

Gold-cholate composite microparticles represent a newly engineered drug delivery platform created via a novel chemical process at the oil-water interface. By introducing gold ions directly at the phase boundary to catalyze particle formation, this technology triggers the assembly of solid microparticles composed primarily of bile salt—a material not previously utilized in solid drug carriers. This technical advance enables unprecedented control over particle size, geometry, and uniform carrier structure, allowing encapsulated water-soluble steroids or bile salt therapeutics to release gradually as the particles degrade. In real-world applications, this versatile platform provides slow, controlled drug release ideal for chronic or targeted therapies across liver disorders, metabolic conditions, and dermatological treatments. By establishing precise control over particle shape and biodistribution, the invention directly addresses growing global market demand for customizable, biocompatible carriers with highly tailored pharmacokinetic profiles.

RELATED TECHNOLOGY

• Bile Salt and Corticosteroid Microparticles for Controlled Release Drug Delivery Applications