Q54 Mouse Model of Epilepsy Caused by Dominant Mutation of Sodium Channel Scn2a

INNOVATION

We generated a transgenic mouse expressing a mutated Scn2a cDNA construct in neurons. The mice have seizures whose severity is dependent on strain background; mild on C57BL/6J and severe on SJL/J. The phenotype of the mice resembles human temporal lobe epilepsy.