Fam83h Conditional Knockout Mouse Model

INNOVATION

This invention provides a Fam83h condition knockout mouse model generated by introducing a specific human mutation in exon 5 of FAM83H gene (Y297X). This mouse model is useful for determining the temporal and spacial expression of Fam83h gene and is important for determining the pathophysiologic effects of Fam83h gene mutation. This mouse model may be used to test genetic or pharmacologic interventions of Fam83h gene defect.