Generation of mice from which Lkb1 (stk11) or both catalytic subunits of AMPK (Prkaa1 and Prkaa2) can be conditionally deleted

We used gene-targeting to generate floxed alleles of Prkaa1 and Prkaa2. Mice bearing either or both of these alleles can be bred with mice that express Cre recombination to conditionally delete Prkaa1 and/or Prkaa2 from cells of interest (depending on the Cre expression pattern). This provides a versatile tool to rigorously study the consequences of AMPK deficiency in cells.

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Jackson https://www.jax.org/strain/014141 https://www.jax.org/strain/014142