GranSim - A Computational Model of Granuloma Simulation (2D & 3D)

OVERVIEW

• GranSim 2D and 3D Models Available
• First released 2004, continually updated
• Substantial Publication History

BACKGROUND

GranSim, the Agent-based model (ABM) describing tuberculosis (TB) granuloma formation and function in the lung, was developed based on four basic concepts: an environment (section of the lung parenchyma), agents (immune cells), ABM rules that govern the agents and their interactions, and the time-step used to update events. The attached documentation illustrates the details of how each of these features have been implemented in the form of a pseudocode. The model was first published in 2004 but has been continually updated to include the latest biological information and technological advances. 

GranSim is a hybrid agent-based computational model (ABM) that describes the formation and function of a granuloma during Mycobacterium tuberculosis infection in the lung. Although granulomas are 3D entities, due to the high computational costs associated to simulate a 3D version, GranSim has been developed and curated since 2004 only in 2D. This website and the recent manuscript [hyperlink here] illustrate our first attempt to simulate a 3D TB granuloma in the lung.