Mice Deficient in Phosphorylation of Eukaryotic Translation Initiation Factor 2 Alpha (eIF2a)

INNOVATION

The Eif2aS51A mutation in these mice prevents phosphorylation of the α subunit of eIF2. Phosphorylation of eIF2α in the endoplasmic reticulum (ER) is required for translational regulation, transcriptional induction, and survival in response to ER stress. These Eif2s1 knock-out mice lack translational and transcriptional regulation in the endoplasmic reticulum. These mice maybe useful in diabetes research.

ADDITIONAL DETAILS