Wdr72 Knockout LacZ Knockin Mouse Model

INNOVATION

WDR72 gene mutations resulted in autosomal recessive hypomaturation amelogenesis imperfecta. The researchers have used gene targeting strategy to generate Wdr72-knockout/lacZ-knockin mice. This mouse model is useful for determining the temporal and spacial expression of Wdr72 gene and is important for determining the phathophysiologic effects of Wdr72 gene absence. This mouse model may be used to test genetic interventions of Wdr72 gene defect.