Mice Genetically Engineered to Lack the Alpha and Delta Isoforms of SH2B1
TECHNOLOGY NUMBER: 2021-493
Technology No. 2021-493
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INNOVATION
The Sh2b1DELα/δ knock-out allele lack the brain-specific alpha and delta Sh2b1 isoforms, but retain the widely expressed beta and gamma isoforms. Sh2b1DELα/δ mice exhibit decreased food intake, protection from weight gain on standard and high-fat diets, and improved glucose homeostasis. These mice may be useful in the study of obesity and metabolism.